Endocrine Abstracts

Introduction: Mechanisms by which visceral obesity and insulin resistance (IR) contribute to atherogenesis are complex and not entirely known. One of the atherogenic factors involved in foam cells formation is scavenger receptor CD36 expressed on monocytes, endothelial cells, adipocytes and platelets, participating in oxidized LDLs absorption and foam cells formation – processes that initiate atheroslerosis. Many factors can influence the expression of receptor CD36.<...

Introduction: Insulin resistance (IR) and visceral obesity, elements of metabolic syndrome (MS), contribute to hyperandogenaemia and may lead to hirsutism and other signs of hyperandrogenism. Little is known about the influence of metformin therapy (MET) on hormonal profile in women with MS and IR without menstrual irregularity.Aim: To asses the influence of MET on sex steroids concentrations in young women with MS.Methods: The stu...

Introduction: Metformin (MET) is mainly used in diabetes mellitus type 2 (DM2) therapy. Little is known about its effects in patients with metabolic syndrome (MS) and insulin resistance (IR) without DM2.Aim: To asses the influence of MET on carbohydrate metabolism in young prediabetic women with MS.Materials and methods: The study population: 30 women with MS aged 25–45 years before (M1) and after (M2) ME...

Introduction: Metabolic syndrome (MS) is connected to atherogenic dyslipidemia. Data concerning influence of metformin (MET) therapy on lipid profile in nondiabetic women with MS remains unclear.Aim: To asses the influence of MET on selected lipid, apolipoproteins AI, B concentrations and atherogenic indexes values in young women with MS.Materials and methods: The study population: 30 women with MS aged 25–45 years before (M<s...